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KMID : 0362720170550120828
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Journal of the Korean Dental Association
2017 Volume.55 No. 12 p.828 ~ p.840
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Regenerative medicine using dental tissue derived induced pluripotent stem cellbiomaterials complex
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Jun Soo-Kyung
Lee Hae-Hyoung
Kim Hae-Won
Lee Jung-Hwan
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Abstract
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In recent years, many researchers and clinicians found interest in regenerative medicine using induced pluripotent stem cells (iPSCs) with biomaterials due to their pluripotency, which is able to differentiate into any type of cells without human embryo, which of use is ethically controversial. However, there are limitations to make iPSCs from adult somatic cells due to their low stemness and donor site morbidity. Recently, to overcome above drawbacks, dental tissue-derived iPSCs have been highlighted as a type of alternative sources for their high stemness, easy gathering, and their complex (ectomesenchymal) origin, which easily differentiate them to various cell types for nerve, vessel, and other dental tissue regeneration. In other part, utilizing biomaterials for regenerative medicine using cell is recently highlighted because they can modulate cell adhesion, proliferation and (de)differentiation. Therefore, this paper will convey the overview of advantages and drawbacks of dental tissue-derived iPSCs and their future application with biomaterials.
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KEYWORD
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Regenerative medicine, dental tissue derived, induced pluripotent stem cell, biomaterials
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